FAQ

Metabolic & Digestive Enzymes: All enzymes are biologically active proteins found in every living cell. Metabolic enzymes catalyze and regulate every biochemical reaction that occurs within the human body, making them essential for cellular function and overall health. Digestive enzymes have a different job, turning the food we eat into energy to be utilized by the body for various biological processes. Our bodies naturally produce both digestive and metabolic enzymes, as they are needed—but sometimes may not produce enough for what we need.

Making Chemical Reactions Happen: Enzymes are protein chemicals, which carry vital energy needed to enable each chemical action and reaction occuring in our body. There are approximately 1,300 different enzymes found in the human cell. These enzymes can combine with coenzymes to form nearly 100,000 various chemicals enabling us to see, hear, feel, move, digest food and think. Every organ, every tissue and all the 100 trillion cells in our body depend upon the reactions of metabolic enzymes and their energy factor. Nutrition would be impossible to explain without describing the part that enzymes play.

Nearly one in three people in the U.S. experience some kind of digestive problem.1,2 Though many suffer, few have to. The typical benefits of enzyme supplementation include reduced digestive distress, increased energy and improved regularity.*

Soothe Digestive Distress:* When undigested foods travel through the intestines, they can irritate and potentially damage the sensitive intestinal wall. Over time, this irritation may reduce our digestive capacity and negatively influence the vital absorption process.

Increase Energy: According to Yuri Elkaim, author of Eating for Energy, in most cases, up to 80% of our body’s vital energy is spent on digestion.3 By aiding the breakdown and absorption of foods, you can free up enormous amounts of energy, increasing physical vitality and enhancing energy levels.*

Promote Regularity: Promoting proper digestion may encourage a healthy intestinal environment and help relieve occasional constipation and irregularity.*

References:

1. “Common GI Problems: Volume 1.” The American College of Gastroenterology. The American College of Gastroenterology, n.d. Web. 30 Jul. 2010 <http://www.acg.gi.org/patients/cgp/cgpvol1.asp>

2. U.S. Census Bureau (2010). Data Finders: Population Clocks. Retrieved October 28, 2010. www.census.gov ,<http://www.census.gov/>

3. Elkaim, Yuri. “Health Benefits of Fasting.” Eating for Energy Blog. Yuri Elkaim, 22 Oct 2009. Web. 2 Aug 2010. <http://eatingforenergy.ca/blog/177/health-benefits-of-fasting/>

Metabolic Enzymes: These are an essential component for optimal cellular function and health—they speed up chemical reactions within cells for detoxification and energy production enabling us to see, hear, feel, move and think. Each organ, every tissue and all 100 trillion cells in our body depend upon the reaction of metabolic enzymes and the energy factor they contribute. Without these metabolic enzymes, cellular life would cease to exist.

Digestive Enzymes: These are secreted along the digestive tract to break food down into nutrients and waste. Most digestive enzymes are produced by the pancreas. The liver, gallbladder, small intestine, stomach and colon also play pivotal roles in the production of these enzymes. Digestive enzymes allow the nutrients found in the foods we consume to be absorbed into the blood stream and waste to be discarded. Some human digestive enzymes include lipase, protease, amylase, ptyalin, pepsin and trypsin.

Food Enzymes: These are introduced to the body through the raw foods we eat and through consumption of supplemental enzyme products. Raw foods naturally contain enzymes, providing a source of digestive enzymes when ingested. However, raw food manifests only enough enzymes to digest that particular food. Cooking and processing of food destroys its enzymes, meaning our bodies have to pick up the slack. Since most of the foods we eat are cooked or processed in some way and because the raw foods we do eat contain only enough enzymes to process that particular food, our bodies must produce the majority of the digestive enzymes we require, unless we use supplemental enzymes to aid in the digestive process. A variety of supplemental enzymes are available through different sources. It is important to understand the differences between the enzyme types and make sure you are using an enzyme product most beneficial for your particular needs.

The Digestive Process: When we eat raw foods, heat and moisture in the mouth activate the enzymes in food. Once active, these enzymes break down the food and make it small enough to pass through the villi (small pores of the intestines) and into the blood.

From the Gut to the Cells: The metabolic enzymes found in the blood then take the digested nutrients and build them into muscles, nerves, bones, blood, lungs and various glands. Every cell in the body depends on certain enzymes to function properly.

Enzyme Specificity: This is referring to the fact that a protein digestive enzyme will not digest a fat, a fat enzyme will not digest a starch (carbohydrate), and so on. Each enzyme has a specific function in the body. This is referred to enzyme specificity.

Staying Unchanged: Enzymes act upon chemicals and change them into other chemicals, but enzymes themselves remain unchanged. Simply stated, enzymes help transform something in our body turning it into something else we need. Without enzymes, nothing in our body could function.

As much as we try to get all the enzymes we need without supplementation, there are a lot of things working against us:

• The process of cooking our food destroys its enzymes, and the processing that gas ripened and irradiated food goes through destroys their enzymes, too.
• As we age, our body’s natural ability to make enzymes decreases.
• Nuts that are raw contain an enzyme inhibitor (as do most beans).
• Many grains and flour are processed, robbing them of their enzymes.

In a world with so many factors keeping us from getting the enzymes we need, enzyme supplements provide support for more complete digestion and nutrient absorption.

The number on the scale doesn’t tell you how much you can bench press or the results of your last blood panel. It can’t tell someone how fast you can run a mile or how much water you drink each day. It doesn’t tell someone how well you sleep or manage daily stressors or how often you go to the gym. But, for the more than 160 million Americans who are “on a diet” at any time, that number does help track progress when working toward maintaining a healthy weight.

Eating a nutrient-rich diet, drinking plenty of water and moving your body regularly are all habits that can be part of a healthy weight management plan. But what about digestive enzymes? Can enzymes be used for healthy weight management? Enzymes speed up digestion, boost energy and break down the macronutrients in your food, turning into fuel.* Read on to learn more about digestive enzymes (including lipase) and the benefits they can offer.*

What are Digestive Enzymes?

Digestion begins before your first bite. Your salivary glands get the signal to start the digestive process, then release your first set of digestive enzymes. After you’ve chewed and swallowed, macronutrients get digested at different stages, with help from the stomach, small intestine, liver and pancreas, the primary producer of digestive enzymes.

Digestive enzymes help break down food into essential nutrients that your body uses for energy and other biological processes. When you don’t have enough enzymes, your digestive system can’t fully break down the foods you eat, which can impact your digestion and transit times. When digestion is sluggish or incomplete, undigested food ferments in the large intestine, which can cause occasional gas, bloating and indigestion.

There are plenty of reasons why you might not have enough digestive enzymes. Aging and everyday stress are common culprits, but lifestyle, habits and an inherited genetic deficiency (like lactose intolerance) can also be to blame. So can overeating or overindulging! Up to 20% of the population has one or more food intolerances due to insufficient enzyme levels. Digestive enzyme supplements can provide the enzymes your body needs (without interfering with your natural production).

How Do Digestive Enzymes Support Health?

For those working to maintain their weight, the motto is “calories in, calories out.” The goal is a calorie deficit (burning more calories than you consume). No matter what’s on your plate – or what you’ve left off – you deserve to feel your best after each meal. Digestive enzymes speed up digestion, boost energy and reduce occasional indigestion.*

Digestive enzymes (like Digest Gold® -- America’s #1 selling digest enzyme supplement formula) break down the foods you eat, to reduce occasional gas and bloating.* While banning the bloat doesn’t move the needle on the scale, it can help you feel more like your best self! Our Thera-blend® enzymes are scientifically formulated for total-body results.* They quickly break down the carbs, dietary fats, fiber and protein in your meals, converting food into fuel (which your body uses to get you through your day).*

You might also be interested in combining enzymes and probiotics. Our Digest Gold® + Probiotics formula delivers all the benefits of digestive enzymes along with 1.5 billion active cultures per daily dose. Those shelf-stable, guaranteed potency probiotics support immune health and regularity while bringing balance back to the gut.*

What is Lipase?

Enzymes are specialists. In the digestive system, each enzyme or group of enzymes targets a certain nutrient. Here’s a quick list.

Enzyme(s)	Nutrient It Breaks Down
Proteases	Proteins
Amylases	Carbohydrates
Lipases	Dietary fats
Cellulase	Fiber
DPP-IV	Gluten (wheat protein)
Lactase	Lactose (milk sugar)
Alpha Galactosidase	Cellulose (plant fiber)
Xylanase	Phenols

Let’s talk more about lipase as an example. Lipase refers to any one of the group of enzymes that break down dietary fats. Just as proteins are made up of amino acid building blocks, the plant- and animal-based fats you consume in your meals need to be broken down.

Lipids are water-insoluble compounds that include oils, waxes and steroids. Fats and oils are made of fatty acids and glycerol. Fatty acids (and glycerol) are the building blocks of fats.  Lipase enzymes help break down lipids and fats into molecules that are small enough to be absorbed into the blood.

They also help your body "unlock" fat-soluble nutrients (such as vitamins A, D, E and K; omega-3 and other fatty acids) so you can absorb them. When you don't have enough lipase enzymes, it's like your body doesn't know what to do with these nutrients. These nutrients are essential for immune, bone, brain and cardiovascular health since they are involved in many functions. That's why lipases are also so important!

For those who are following a ketogenic or higher-fat diet, supplementing with lipase can boost digestion of the added fats.

Lypo Gold™ can break down up to 22 grams of dietary fat per capsule, making it keto diet-friendly.* Also helpful for those without gallbladders, this formula relieves discomfort associated with the digestion of fatty foods.*

How to Choose Quality Digestive Enzymes

Enzymes are not weighed in metric units like milligrams or grams. They're also not measured like recipes, in dashes or teaspoons. That is just not the way that digestive enzymes function! Enzymes instead are always measured according to their respective activity levels, utilizing a certain set of purity, quality and identity of food ingredients standards established by the internationally accepted Food Chemical Codex. As the industry leader in digestive enzymes for over 20 years, we know this -- and we always follow the Codex. So you will see that no matter which of our products you take for your digestive health, there will always be a rating of each enzyme's activity levels. Look at any of our products, and you'll see the "Supplement Facts" label. We have nothing to hide, so we provide the various types and activity levels of each enzyme or combination, as well as the specific activities included with each one.

Regardless of the formula that you choose, it will contain Enzymedica's proprietary Thera-blend® technology. That means that the enzymes will be guaranteed to work throughout the entire pH spectrum found along your GI tract. When other brands’ enzyme formulas may fall short or simply not work, our enzymes will be effective in almost all acidic or alkaline environments.

Products You Might Like

Digest Gold™ breaks down your biggest meals. Take daily with each meal to enjoy the foods you love and beat the bloat – with no gas or discomfort!* With bloat-busting, high-potency enzymes, Digest Gold™ is the gold standard for digestive enzymes, as proven by its ongoing status as the number one best-selling enzyme formula in the US for over 10 years and counting. With Thera-blend™ enzymes, it quickly breaks down carbs, fats, fiber and protein. Plus, it prevents that too-full feeling and converts food into fuel with ATPro™ for greater energy!*

Digest™ delivers full-range, everyday enzymes. This formula helps you enjoy the foods you love when taken daily with each meal. It eliminates bloat (for no gas or discomfort)! Digest Complete effectively breaks down carbs, fats, fiber and protein. It speeds digestion and helps absorb nutrients. And it converts daily meals into all-day energy.

Digest Basic™ breaks down the simplest meals – so you can enjoy the foods you love.* Take it daily with each meal to ease bloat (for no gas or discomfort). These essential, easy-on-you enzymes gently and effectively break down fats, fiber, protein, carbs and hard-to-digest foods. Digest Basic prevents indigestion and converts food into vital energy.

Of all enzyme sources—plant, glandular and vegetarian—vegetarian is the most active, or potent. This means they contain more active units and can break down more fat, protein and carbohydrates across a broader range than any other source. This is why vegetarian enzymes make up 80% of the enzyme supplements sold in health food stores today.

Our bodies produce two kinds of enzymes: digestive and metabolic. Digestive enzymes help us to digest food, and metabolic enzymes allow the necessary actions for life to occur in our cells. By allowing our bodies to produce less digestive enzymes, it frees the body up to produce more metabolic ones, helping us to live healthier lives.

The most common enzymes found in natural food supplements are protease, lipase, amylase and cellulase. All four of these vegetarian enzymes, the most potent form of enzymes, are found in Enzymedica’s complete digestive supplements such as Digest Gold.

Vegetarian Enzymes: These are the most popular choice of supplemental enzymes. They are grown in a laboratory setting and extracted from certain types of fungi and probiotics. The enzymes harvested from aspergillus are called vegetarian, or fungal. Of all the choices, vegetarian enzymes are the most potent. This means they can break down more fat, protein and carbohydrates than any other source. Two common vegetarian enzymes are bromelain and papain.

Bromelain: This is a proteolytic (breaks down protein) and milk-clotting enzyme derived from the pineapple stem. A concentrate of this enzyme has been known to promote a healthy inflammatory response, is used as a meat tenderizer and is used in the chill-proofing of beer.* Like pepsin and papain, bromelain has an optimal temperature higher than normal body temperature. There is always greater heat at the sight of inflammation than any other part of the body. Bromelain is used in Repair, Repair Gold and Natto-K.

Papain: This is an enzyme derived from the latex of papaya. This enzyme becomes active in an environment of 6.0-8.0 pH and requires temperatures above normal human body temperature. Like bromelain, it too supports the body’s natural recovery from overexertion.*

Glandular/Animal: Chymotrypsin, pancreatin, pepsin and trypsin are enzymes from the pancreas, stomach and small intestine derived from animal glands and organs. These enzymes require an alkaline pH level of 8.0 to become active. Enzymedica products are 100% vegetarian, thus, enzymes derived from animals are not used in Enzymedica enzyme formulations.

Each of our enzyme supplements is designed to meet a specific need. To find out what product would be best for you, take our digestive quiz.

CoQ10, vitamins and minerals are all coenzymes, which means they need energy and another enzyme to work. Blue green algae and green barley are helpful, but since they are not enzymes, they cannot help us absorb nutrients from everything we eat. Hydrochloric acid can help digestion but is not an enzyme nor does it act as an enzyme.

Raw food provides only enough enzymes to digest that particular food. There are no extra enzymes in raw food to digest the other cooked or processed food we eat. Although a totally raw diet may appear to be the best solution, it is generally not practical, and in most cases, not medically advisable. Due to the risk of bacterial contamination, many foods should not be eaten raw, including meats, poultry, eggs and beans. Many people also find the fiber content in large quantities of raw food difficult to digest.

Since enzymes are the catalysts that turn food into energy, they're necessary to make muscles move and grow. If muscle tissue enzymes were not working in the muscle tissue, there would be no muscular growth, not even the basic muscular activity to create growth. So, enzyme supplementation can ensure you're getting the maximum benefit out of the food you're consuming—better supporting body performance.*

No. GlutenEase was designed for individuals with gluten intolerance and was never intended to “cure” celiac or any other known disease. Some people suffering with Celiac disease find GlutenEase helpful as a safety precaution when eating outside of one's own home.

Digestive products such as Lacto or Digest Spectrum are good choices to take with meals, while products found with the “red labeling,” such as Candidase, are suggested between meals. Many children with autism are found to have food intolerance issues, and alleviating that problem area can lead to results in other areas of their behavior.

No matter which product you choose, we recommend using the “low and slow” dosing method. This means slowly building up tolerance to enzymes and increasing potency over time.

Enzymedica takes great pride in producing safe and effective high-quality supplemental enzyme products. Our enzymes come from sources that have not come into contact with any pesticides or preservatives, however, they are not considered “certified organic.”

First off, always avoid fillers such as magnesium stearate, apple pectin and rice starch. When looking at the label of a high-quality enzyme product, you will find measurement units you may not recognize. With most supplements, we are used to comparing products based on weight. However, with enzymes, we are interested in the activity and potency available, which is measured in these specific units. It is important to recognize that there is no direct relationship between weight and enzyme activity.

When comparing enzyme products make sure enzyme activities are measured using units such as these:

 

• Alpha-Galactosidase - GALU (Galactosidase Units)
• Amylase - DU (Dextrinizing Units)
• Bromelain - GDU (Gelatin Digesting Units) or FCCPU
• Catalase - Baker Units (Named after the author)
• Cellulase - CU (Cellulase Unit)
• Glucoamylase - AGU (Amyloglucosidase Units)
• Hemicellulase - HCU (Hemicellulase Units)
• Invertase - INVU (Invertase Activity Unit) or SU (Sumner Units)
• Lactase - ALU (Acid Lactase Unit)
• Lipase - FCCFIP (Federation Internationale Pharmceutique)
• Maltase - DP (Degrees of Diastatic Power)
• Nattokinase - FU (Fibrinolytic Units)
• Pectinase - Endo-PGU (Endo-Polygalacturonase Units)
• Phytase - FTU (Phytase Units)
• Protease-HUT (Hemoglobin Unit on a L-Tyrosine Basis)
• Xylanase - XU (Xylanase Units)

If you see a warning on a product label stating “WARNING: Reproductive Harm – www.P65Warnings.ca.gov”, don’t be alarmed. This warning is required to be on certain products sold to the state of California, and warnings like this one are commonly posted throughout California, including restaurants, grocery stores, gas stations, hotels, schools, hospitals and on consumer products.

You may be surprised to find this warning on everyday items like wine, vinegar, alcohol, potato products, nutritional supplements, cleaning products, etc.

Why is this warning specific for California?
In 1986, the State of California enacted the Safe Drinking Water and Toxic Enforcement Act, commonly known as Prop 65. California voters approved of this initiative to require businesses to notify California residents of their exposure to chemicals from consumer products, at home and the workplace, and from the environment.

Today, California has incorporated more than 800 chemicals to their growing list of substances “known to the State of California” to cause cancer and/or birth defects or other reproductive harm. Although these chemicals are regulated both federally and internationally for safety, California has set their own standards known to be more stringent than any other regulation.

Why is this warning statement on my product?
Since chemicals, such as lead, are naturally present in small amounts throughout the environment, herbal and botanical ingredients from plants grown in soil are expected to contain very small amounts of this heavy metal. Because of this, we verify that our formulas comply with regulatory standards. California’s lead limit is 20 times less than the federal limit, therefore it is common to see a warning statement on dietary supplements containing botanical ingredients.

Enzymedica® is dedicated to complying with all regulatory standards to provide our customers with the highest quality supplements and encourage vibrant health.

Unlike certain vitamins, minerals and herbs, there is no upper limit (or threshold) to the number of supplemental enzymes that can be consumed. The reason for this is that the body has an estimated 100 trillion cells, and any one of those cells could be using thousands of different enzymes every second. This allows for huge quantities to be used by the body without overdosing.

Supplemental enzymes support the body’s normal function without replacing its ability to make enzymes on its own. We like to compare this to a raw food diet that is rich in enzymes. Even though you would be ingesting a large amount of enzymes through your food, no one suggests eating raw food would inhibit the body’s natural production of digestive enzymes. The fact is, the body will continue to manufacture the enzymes needed to benefit from food. Supplemental digestive enzymes simply aid the digestive process.

Vegetarian enzymes tolerate stomach acid well and are not destroyed. Enzymedica’s exclusive Thera-blend™ technology combines vegetarian enzymes formulated to perform across a wide pH range, including acidic and alkaline environments. This enables enzymes to not only be active in the stomach, but throughout the entire GI tract in order to optimize digestive benefits.

We believe our supplemental enzymes, as they are naturally occurring, are among the safest nutritional supplements available. However, with a lack of conclusive scientific evidence, we recommend consulting a physician before combining or replacing prescription drugs with supplemental enzyme products.

Some individuals insist that the effects of digestive enzymes can be felt more quickly than other nutritional products. Most people begin to really feel the effects after a few days to a few weeks.